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They are characterized by a longer clinical history and have a better prognosis than primary GBM

While early polymeric formulations such as NanoCurc established the foundational feasibility of systemic curcumin delivery in preclinical models [190, 191], specifically extending median survival from 28 to 63 days in xenograft models, recent researches have pivoted toward smart multifunctional nanocarriers designed to actively breach these stromal barriers and reprogram the TME [192]

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It also identified several polymorphisms that play into fibroid development, including several that affect oncogenesis, immune factors, cell metabolism and migration, collagen formation, and endogenous antioxidant systems like Nrf2

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