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In addition, reduced TRX-2 expression further impaired the antioxidant capacity of the cells

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A moderate increase in ROS levels can stimulate cell growth and proliferation, and allows for the normal physiological functions

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4 Neuroprotective strategies Risk factors for OIPN consist of dose per cycle, cumulative dose, treatment regimen, duration of infusion, administration of chemotherapeutics, comorbidity and pre-existing peripheral neuropathy (Miltenburg and Boogerd, 2014)

doi: 10.1016/j.canlet.2014.12.015