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Because specific vitamins and minerals work antagonistically to one another, consuming large amounts of isolated supplements like B1 (thiamine) can contribute to a deficiency in vitamin B6 over time

For adults who tolerate 2.4 mg for at least four weeks and need additional weight reduction, the current label allows a maximum of 7.2 mg weekly

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All but the most severe of cases can be successfully managed through lifestyle changes in diet and physical activity alone, although low compliance has encouraged interest in effective therapies, including gastrointestinal surgery (efficacious and long-lasting, but limited in use because of associated risks and costs) and pharmacological interventions