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Despite the first publication of this finding by Kuzminski in 1998, (5) a survey of Canadian physicians in 2007 revealed that 5.6% used oral vitamin B12 as an alternative to intramuscular injections and that only 25% of physicians were aware of the published trial

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doi: 10.1016/j.canlet.2020.02.015 13 ZhangRChenJWangSZhangWZhengQCaiR

16 However, as individual responses to these drugs may vary inexplicably, it is reasonable to offer patients a trial of a different PDE5 inhibitor before proceeding to more invasive treatments

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