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There was no difference in the rate of major malformations between women exposed to PPIs and the control group, corresponding to a Relative Risk (RR)=1.04, [95% Confidence Interval (CI) 0.25-4.21]

GCK also exerts joint protection by inhibiting the proliferation, migration and secretion of synovial cells (129), whose molecular mechanism is to inhibit the secretion of TNF- in AIA-FLS rats, down-regulate the expression of tumor necrosis factor receptor type 2 (TNFR2), and inhibit TNF--mediated proliferation, migration and secretion of AIA -FLS

Apoptosis Apoptosis is the most common noninflammatory form of programmed cell death [182, 255]

It was demonstrated that the MSC-Ex triggered the increased expression of SLC7A11 protein, CD44 and OTUB1, and the activation of system XC to prevent ferroptosis (119)