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These observed features of reduced gut microbiota may explain the persistent intestinal inflammation in CD patients in smoky environment, highlighting the possible role of microbes interacting with smoking and CD (or mediating the adverse effects of smoking in CD)

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Establish a smoke-free environment by removing tobacco products, lighters and ashtrays from homes, cars, and other places where you spend a lot of time

MR-Egger-SIMEX can provide estimation with adjustment for dilution of the MR-Egger estimate using the simulation extrapolation (SIMEX) method, as a supplementary tool for MR-Egger when I 2 GX 0.05)

ELISA (Enzyme-Linked Immunosorbent Assay): A lab-based method that uses antibodies to detect specific compounds, such as cotinine

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