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Cell Res 18 , 1726, (2008)

When IGF-1 binds to the subunit of IGF-1R, it triggers the -subunits of the receptor to exhibit intrinsic tyrosine kinase activity

In the hydrogel delivery system, UA can be constructed with cisplatin (DDP) as a co-loaded pectin/cellulose hydrogel, which acts on mouse lung cancer (LA795) cells to inhibit the proliferation, migration and promote apoptosis of lung cancer cells by inhibiting the TMEM16A, regulating the MAPK and EMT signaling pathways and other mechanisms [1087]