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Hyperactivation of the SSP increases the supply of substrates for m6A methylation, further sustaining the high expression of PCK2 and NRF2, ultimately resulting in significantly reduced sensitivity of hepatocellular carcinoma cells to lenvatinib (62)

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Most of the mature cathelicidins are linear peptides that adopt an -helical fold with an amphipathic character when exposed to hydrophobic environments (e.g., biological membranes), but -sheet structures stabilized by disulfide bonds, loop structures or extended polyproline structures are also known [104]

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