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When oxidized, the primary structure of Hb is altered by the establishment of disulfide cross-links between globin chains that make the molecule unstable, leading to the formation of Heinz bodies and, eventually, to a premature RBC removal [11]

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When aged rats were supplemented with ascorbate, pulmonary GSH increased [146], and total glutathione and GSH/GSSG ratios increased in chronically loaded muscles [9]

Inclusion and exclusion criteria The systematic review protocol was established using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines

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