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doi: 10.1097/01.CCM.0000254340.91644.B2 12 ChalmersJDSinganayagamAMurrayMPScallyCFawziAHillAT

These antigens are found in significantly higher amounts in the peripheral blood of patients vs healthy individuals

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In addition to these endogenous sources, exogenous factors such as environmental stresses, accidental leakage of high-dose radiation or ultraviolet light, bacterial infections, and ingestion of harmful chemicals also promote ROS production [4]