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Nature 553 , 96100 (2018)

Another pathway through which polyphenols can increase insulin sensitivity is by activating AMP-activated protein kinase (AMPK), an essential regulator of energy metabolism (Xie et al., 2023)

Besides SOD and APX that directly scavenge ROS, this cycle also involves other enzymes such as MDHAR, DHAR, and GR, which act as antioxidant-regenerating enzymes that regenerate GSH and ASA from their oxidized forms (Mittler, 2002