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4.1.2 Stabilizing mitochondrial function in neurodegenerative models Loss of mitochondrial membrane potential (MMP), impaired ATP synthesis, and heightened oxidative/nitrosative stress can contribute to neuronal apoptosis and cognitive decline (Finsterer, 2012)

Elevated heme levels are a hallmark of multiple cancers, reflecting an adaptive rewiring of metabolism rather than a passive accumulation

doi: 10.1016/j.sjbs.2023.103779

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Historically, peroxiredoxins have been divided into three classes: typical 2-Cys PRXs, atypical 2-Cys PRXs, and 1-Cys PRXs

However, it also inhibits NOX-2, -3 and -4 and XO to some extent