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Most features of CKD-MBD are usually present by the time eGFR falls below 45 (stage 3b), though bone disease can begin as soon as stage 2 (eGFR 60 to 89)

Furthermore, the expected shift in population dynamics, with seniors projected to outnumber children under 12 by 2050 underlines their importance in promoting healthy aging and decreasing healthcare burden

Polysaccharides also regulate endogenous antioxidant enzymes such as superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px), via the Nrf2/ARE axis (146, 147)

Digitized information is comprised of a pattern of 1s and 0s

The reaction was started by adding 0.05 ml of the supernatant to 1 ml of 0.03% (v/v) H 2 O 2 in 60 mm TrisHCl buffer (pH 7.0)