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Alternative Routes of Administration & the First-Pass Effect There are several reasons for different routes of administration used in clinical medicine ( Table 33 )for convenience (eg, oral), to maximize concentration at the site of action and minimize it elsewhere (eg, topical), to prolong the duration of drug absorption (eg, transdermal), or to avoid the first-pass effect (sublingual or rectal)

After adjusting the cell concentration to 37,000 cells per ml, 2 ml of cell suspension was added to the transfection mix into a well of a six-well plate

Commonly, the term is used loosely to refer to the combined action of sunlight and air, which cause oxidation and hydrolysis

Narrative flow of study selection A total of 612 records were identified through database searching (PubMed = 205, Scopus = 188, Web of Science = 172, Google Scholar = 47)

In the early stage of the disease, the clinical manifestations of cataracts are often not significant

Psychiatry 7:1294