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No data were excluded from analysis

Comp Clin Pathol 28:14551464 Chen Z et al (2020) Assessment of PPARGC1A, PPARGC1B, and PON1 genetic polymorphisms in esophageal squamous cell carcinoma susceptibility in the Eastern Chinese Han population: a casecontrol study involving 2351 subjects

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5.3 Tryptophan metabolites Tryptophan metabolites are generated either through direct decomposition of tryptophan by gut microbiota (e.g., Clostridium, Escherichia coli ) into indole derivatives (such as IPA and indole-3-acetic acid (IAA)) or via host-cell-mediated processes (e.g., indoleamine 2,3-dioxygenase 1(IDO1)-catalyzed kynurenine production, 5-hydroxytryptamine (5-HT) synthesis by enterochromaffin cells) in coordination with microbial metabolism